The Hottest New Cancer Drugs Depend on Gut Microbes
Immunotherapy doesn’t work for everyone, and a series of new studies might explain why.
The combination—feces and drug—was even more effective.
The two strains of mice differed in the numbers of more than 250 microbes, but only one genus—Bifidobacterium (or Bifs, for short)—was consistently associated with anti-tumor T-cells. The numbers of these microbes went up by more than 400 times when the TAC mice ate the cancer-controlling JAX stools. And by deliberately giving Bifs to mice, Gajewski’s team boosted their ability to make anti-tumor T-cells, and to control their tumors.